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Resistance to amphotericin B associated with defective sterol Δ8→7 isomerase in a Cryptococcus neoformans strain from an AIDS patient

Steven L. Kelly, David C. Lamb, Mark Taylor, Andrew J. Corran, Brian C. Baldwin, William G. Powderly
DOI: http://dx.doi.org/10.1111/j.1574-6968.1994.tb07140.x 39-42 First published online: 1 September 1994


Two Cryptococcus neoformans strains isolated from an AIDS patient were investigated, a pretreatment isolate (CN1) and a second isolate (CN3) following failure of fluconazole and amphotericin B treatment. No difference in fluconazole sensitivity, but relative resistance to amphotericin B was observed for CN3. The sterol composition of CN3 indicated a defect in sterol Δ8→7 isomerase in this strain and depletion of ergosterol, the major sterol of the CN1.

Key words
  • Resistance
  • Amphotericin B
  • Cryptococcus neoformans

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