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Role of ribosome degradation in the death of heat-stressed Salmonella typhimurium

Tim Tolker-Nielsen, Søren Molin
DOI: http://dx.doi.org/10.1111/j.1574-6968.1996.tb08423.x 155-160 First published online: 1 September 1996


Heat treatment of Salmonella typhimurium results in cell death, which coincides with a significant reduction of the cellular content of 16S ribosomal RNA. It is suggested that the degradation of ribosomal RNA is a direct cause of cell death. This conclusion is based on the observations of carbon-starved and magnesium-supplemented cells, which survive heat treatment much better, and which also maintain stable levels of ribosomal RNA.

  • Heat treatment
  • Ribosomal RNA degradation
  • Cell death
  • Salmonella typhimurium