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Eva Lorenz, George V. Stauffer, MetR-mediated repression of the glyA gene in Escherichia coli, FEMS Microbiology Letters, Volume 144, Issue 2-3, November 1996, Pages 229–233, https://doi.org/10.1111/j.1574-6968.1996.tb08535.x
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Abstract
Inactivation of either of the two MetR binding sites centered at bp —143 and —121 relative to the +1 transcription start site results in reduced glyA-lacZ expression in a wild-type strain below the level seen in a metR mutant. This reduced expression is dependent on the side of the DNA helix MetR binds relative to the RNA polymerase binding site. Thus, a single MetR dimer bound to the DNA may play a physiological role in maintaining appropriate glyA gene expression, functioning as a represser under low MetR conditions.
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