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Evidence that mucoid Pseudomonas aeruginosa in the cystic fibrosis lung grows under iron-restricted conditions

Michael R.W. Brown , Hosmin Anwar , Peter A. Lambert
DOI: http://dx.doi.org/10.1111/j.1574-6968.1984.tb00195.x 113-117 First published online: 1 January 1984


The outer membrane protein composition of mucoid Pseudomonas aeruginosa recovered without subculture from the sputum of a cystic fibrosis patient was studied by sodium dodecyl sulphate-polyacrylamide gel electrophoresis. The results indicated that three outer membrane proteins in the range of Mr 80 000–90 000 were induced. The induction of these proteins can be simulated by growing the same isolate under iron-restricted conditions in laboratory media. This initial study gives the first direct biochemical evidence that mucoid P. aeruginosa grows under iron restricted conditions in the lungs of the cystic fibrosis patient.

  • Pseudomonas aeruginosa
  • iron-restriction
  • cystic fibrosis
  • outer membrane proteins

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