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Inability of men mutants of Escherichia coli to use trimethylamine-N-oxide as an electron acceptor

R. Meganathan
DOI: http://dx.doi.org/10.1111/j.1574-6968.1984.tb01244.x 57-62 First published online: 1 September 1984


Mutants of Escherichia coli blocked in the biosynthesis of menaquinone were unable to use trimethylamine-N-oxide as an electron acceptor in complex medium containing glucose. Trimethylamine-N-oxide reduction and the consequent in-crease in growth could be restored in a menC mutant by either o-succinylbenzoic acid (OSB) or 1,4-dihydroxy-2-naphthoic acid (DHNA). In the case of a menB mutant, growth could not be restored by OSB; but addition of DHNA resulted in the restoration of growth to the full extent. These results are consistent with the metabolic blocks in the respective men mutants.

  • Vitamin K2
  • menaquinone
  • o-succinylbenzoate
  • 1,4-dihydroxy-2-naphthoate

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