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Long-term persistence of scrapie infection in mouse spleens in the absence of clinical disease

S.C. Collis , R.H. Kimberlin
DOI: http://dx.doi.org/10.1111/j.1574-6968.1985.tb00844.x 111-114 First published online: 1 August 1985

Summary

Studies were made of the 87V strain of scrapie in IM mice (Sincp7) to discover why the intracerebral route of injection of a 1% brain inoculum produced clinical scrapie but the intraperitoneal route did not. It was found that the intraperitoneal route rapidly established a persistent infection in spleen (and presumably other extraneural tissues) without there being any significant spread of infection to the brain during the 1.5 year period of observation.

Keywords
  • Mouse
  • persistent infection
  • scrapie
  • spleen

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